General Information

  • ID:  hor001078
  • Uniprot ID:  NA
  • Protein name:  SEPYLRFamide
  • Gene name:  NA
  • Organism:  Helix lucorum
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SEPYLRF
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  acts as an inhibitory modulator of acetylcholine (ACh) receptors
  • Mechanism:  Na/Ca-exchange and intracellular Ca2+ released from internal pools containing TG-sensitive Ca2+-pump are involved in the Na,K-pump pathway
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001078_AF2.pdbhor001078_ESM.pdb

Physical Information

Mass: 101821 Formula: C43H62N10O12
Absent amino acids: ACDGHIKMNQTVW Common amino acids: EFLPRSY
pI: 6.4 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -72.86 Boman Index: -1737
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 55.71
Instability Index: 9111.43 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  17049630
  • Title:  Involvement of Na,K-pump in SEPYLRFamide-mediated reduction of cholinosensitivity in Helix neurons.